Ontology highlight
ABSTRACT:
SUBMITTER: Young BF
PROVIDER: S-EPMC6440844 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Young Brandon F BF Roth Braden M BM Davies Christopher C
Biomolecular NMR assignments 20181001 1
Gonorrhea infections are becoming more difficult to treat due to the prevalence of strains exhibiting resistance to antibiotics and new therapeutic approaches are needed. N-acetylmuramyl-L-alanine amidase (AmiC) from Neisseria gonorrhoeae is a hydrolase that functions during cell division by cleaving the bond between the N-acetylmuramyl and L-alanine moieties of peptidoglycan. Inhibiting this enzyme offers the prospect of restoring the efficacy of existing antibiotics as treatments against N. go ...[more]