Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC6441008 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Wang Yang Y Park Jae-Hyun JH Lupala Cecylia Severin CS Yun Ji-Hye JH Jin Zeyu Z Huang Lanqing L Li Xuanxuan X Tang Leihan L Lee Weontae W Liu Haiguang H
Scientific reports 20190329 1
CXCR1, a member in G-protein coupled receptor (GPCR) family, binds to chemokine interleukin-8 (IL-8) specifically and transduces signals to mediate immune and inflammatory responses. Despite the importance of CXCR1, high-resolution structure determination is hindered by the challenges in crystallization. It has been shown that properly designed mutants with enhanced thermostability, together with fusion partner proteins, can be useful to form crystals for GPCR proteins. In this study, in silico ...[more]