Ontology highlight
ABSTRACT:
SUBMITTER: Kantidze OL
PROVIDER: S-EPMC6441033 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Nature communications 20190329 1
Recently we characterized a class of anti-cancer agents (curaxins) that disturbs DNA/histone interactions within nucleosomes. Here, using a combination of genomic and in vitro approaches, we demonstrate that curaxins strongly affect spatial genome organization and compromise enhancer-promoter communication, which is necessary for the expression of several oncogenes, including MYC. We further show that curaxins selectively inhibit enhancer-regulated transcription of chromatinized templates in cel ...[more]