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The same domain of Su(Hw) is required for enhancer blocking and direct promoter repression.


ABSTRACT: Suppressor of Hairy-wing [Su(Hw)] is a DNA-binding architectural protein that participates in the organization of insulators and repression of promoters in Drosophila. This protein contains acidic regions at both ends and a central cluster of 12 zinc finger domains, some of which are involved in the specific recognition of the binding site. One of the well-described in vivo function of Su(Hw) is the repression of transcription of neuronal genes in oocytes. Here, we have found that the same Su(Hw) C-terminal region (aa 720-892) is required for insulation as well as for promoter repression. The best characterized partners of Su(Hw), CP190 and Mod(mdg4)-67.2, are not involved in the repression of neuronal genes. Taken together, these results suggest that an unknown protein or protein complex binds to the C-terminal region of Su(Hw) and is responsible for the direct repression activity of Su(Hw).

SUBMITTER: Melnikova L 

PROVIDER: S-EPMC6441048 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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The same domain of Su(Hw) is required for enhancer blocking and direct promoter repression.

Melnikova Larisa L   Elizar'ev Pavel P   Erokhin Maksim M   Molodina Varvara V   Chetverina Darya D   Kostyuchenko Margarita M   Georgiev Pavel P   Golovnin Anton A  

Scientific reports 20190329 1


Suppressor of Hairy-wing [Su(Hw)] is a DNA-binding architectural protein that participates in the organization of insulators and repression of promoters in Drosophila. This protein contains acidic regions at both ends and a central cluster of 12 zinc finger domains, some of which are involved in the specific recognition of the binding site. One of the well-described in vivo function of Su(Hw) is the repression of transcription of neuronal genes in oocytes. Here, we have found that the same Su(Hw  ...[more]

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