Ontology highlight
ABSTRACT:
SUBMITTER: Krimpenfort P
PROVIDER: S-EPMC6441055 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Krimpenfort Paul P Snoek Margriet M Lambooij Jan-Paul JP Song Ji-Ying JY van der Weide Robin R Bhaskaran Rajith R Teunissen Hans H Adams David J DJ de Wit Elzo E Berns Anton A
Nature communications 20190329 1
Cdkn2ab knockout mice, generated from 129P2 ES cells develop skin carcinomas. Here we show that the incidence of these carcinomas drops gradually in the course of backcrossing to the FVB/N background. Microsatellite analyses indicate that this cancer phenotype is linked to a 20 Mb region of 129P2 chromosome 15 harboring the Wnt7b gene, which is preferentially expressed from the 129P2 allele in skin carcinomas and derived cell lines. ChIPseq analysis shows enrichment of H3K27-Ac, a mark for activ ...[more]