Ontology highlight
ABSTRACT:
SUBMITTER: Lima-Fernandes E
PROVIDER: S-EPMC6441108 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Nature communications 20190329 1
In embryonic stem cells, promoters of key lineage-specific differentiation genes are found in a bivalent state, having both activating H3K4me3 and repressive H3K27me3 histone marks, making them poised for transcription upon loss of H3K27me3. Whether cancer-initiating cells (C-ICs) have similar epigenetic mechanisms that prevent lineage commitment is unknown. Here we show that colorectal C-ICs (CC-ICs) are maintained in a stem-like state through a bivalent epigenetic mechanism. Disruption of the ...[more]