The identification of differentially expressed genes between extremes of placental efficiency in maternal line gilts on day 95 of gestation.
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ABSTRACT: BACKGROUND:Placental efficiency (PE) describes the relationship between placental and fetal weights (fetal wt/placental wt). Within litters, PE can vary drastically, resulting in similarly sized pigs associated with differently sized placentas, up to a 25% weight difference. However, the mechanisms enabling the smaller placenta to grow a comparable littermate are unknown. To elucidate potential mechanisms, morphological measurements and gene expression profiles in placental and associated endometrial tissues of high PE and low PE feto-placental units were compared. Tissue samples were obtained from eight maternal line gilts during gestational day 95 ovario-hysterectomies. RNA was extracted from tissues of feto-placental units with the highest and lowest PE in each litter and sequenced. RESULTS:Morphological measurements, except placental weight, were not different (P?>?0.05) between high and low PE. No DEG were identified in the endometrium and 214 DEG were identified in the placenta (FDR?
SUBMITTER: Krombeen SK
PROVIDER: S-EPMC6441153 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
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