Dataset Information

Compendium of hand, foot and mouth disease data in Malaysia from years 2010-2017.

ABSTRACT: This data article is constructed using information from hand, foot and mouth disease outbreaks in every Malaysian state. Important information like total number of cases from every state and age group, humidity, air temperature and wind as well as types of viruses isolated from patients infected with hand, foot and mouth disease were gathered and sorted into four tables. The information sources include Malaysian Administrative Modernisation and Management Planning Unit (MAMPU), National Centre for Biotechnology Information (NCBI) and National Oceanic and Atmospheric Administration (NOAA). Since the Ministry of Health Malaysia only begun archiving hand, foot and mouth disease cases between years 2010-2017 in MAMPU, weather data extractions are following the similar timeline. Conversely, published data on viruses and their serotypes associated to hand, foot and mouth disease were extracted from NCBI but, data availability were limited between the years 2010 and 2014.

SUBMITTER: Nelson BR

PROVIDER: S-EPMC6441719 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Compendium of hand, foot and mouth disease data in Malaysia from years 2010-2017.

Nelson Bryan Raveen BR Edinur Hisham Atan HA Abdullah Mohd Tajuddin MT

Data in brief 20190320

This data article is constructed using information from hand, foot and mouth disease outbreaks in every Malaysian state. Important information like total number of cases from every state and age group, humidity, air temperature and wind as well as types of viruses isolated from patients infected with hand, foot and mouth disease were gathered and sorted into four tables. The information sources include Malaysian Administrative Modernisation and Management Planning Unit (MAMPU), National Centre f ...[more]

PMID: 30976640

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Project description:Hand, foot, and mouth disease (HFMD) is well recognized as one of the major threats to children's health globally. The increasing complexity of the etiology of HFMD still challenges disease control in China. There is little surveillance of the molecular epidemiological characteristics of the enteroviruses (EVs) that cause HFMD in Neijiang city or the Sichuan Basin area in Southwest China. In this study, demographic and epidemiological information for 14,928 probable HFMD cases was extracted and analyzed to describe the epidemic features of HFMD in Neijiang city from Jan 2010 to Dec 2017. The swab samples of select probable HFMD cases from 2012 to 2017 were tested by reverse transcription (RT) real-time PCR to identify the serotype distribution of EVs, and 110 randomly selected RT-real-time PCR positive samples were then amplified and analyzed for the VP1 or VP4 regions of EVs to further analyze the phylogenetic characteristics of the circulating strains in this area. The eight-year average annual incidence was 49.82 per 100,000 in Neijiang. The incidence rates varied between 19.51 and 70.73 per 100,000, demonstrating peaks of incidence in even-number years (2012, 2014 and 2016). The median age of the probable cases was 27 months and the interquartile range (25th to 75th percentile) of ages for the probable HFMD cases was between 14 and 42 months. The male-to-female ratio of the probable HFMD cases was 1.47:1, and scattered children were the major population classification (81.7%). Two epidemic peaks were observed: one major peak between April and July and the other lesser peak between October and December. Of 6513 probable cases tested with RT-real-time PCR, 4015 (61.6%) were positive for enterovirus with the serotype distribution as follows: EV71+, 30.1% (n = 1210); CV-A16+, 28.7% (n = 1154) and a sole pan-enterovirus+, 41.1% (n = 1651). A total of 91 cases (82.7%, 91/110) were successfully amplified and underwent phylogenetic analysis: all EV71+ cases were C4a serotype (n = 23/30); all CV-A16+ cases were B2b serotype (n = 24/30); of 42 sole pan-enterovirus+ samples, 20 were CV-A6, 14 were CV-A10 and the rest within this group were CV-A4 (n = 4), CV-A8 (n = 2), CV-A9 (n = 1) and CV-B3 (n = 1). Our findings provide important evidence that aids the improvement of strategies for vaccination against HFMD and comprehensive disease control in China.

Dataset Information

Compendium of hand, foot and mouth disease data in Malaysia from years 2010-2017.

Publications

Compendium of hand, foot and mouth disease data in Malaysia from years 2010-2017.

Similar Datasets

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