Physiologic response to pre-arrest bolus dilute epinephrine in the pediatric intensive care unit.

ABSTRACT: AIM:To quantify the physiologic effects of pre-arrest bolus dilute epinephrine in the pediatric intensive care unit. METHODS:Patients <18?years old and ?37 weeks gestation who received an intravenous bolus of dilute epinephrine (10?mcg/mL) in the pediatric intensive care units at our institution from January 2011 to March 2017 were retrospectively identified. Patients were excluded if doses exceeded 20?mcg/kg, or under the following circumstances: orders limiting resuscitation, extracorporeal membrane oxygenation, active chest compressions, simultaneous administration of other blood pressure-altering interventions or documented normotension prior to epinephrine. The primary outcome was change in systolic blood pressure within 5?min of epinephrine. Patients were categorized as non-responders if the change in systolic blood pressure was ?10?mmHg. RESULTS:One hundred forty-four patients were analyzed. The median index dose was 0.7 mcg/kg (IQR, 0.3-2.0), and the mean increase in systolic blood pressure was 31?mmHg (95% CI, 25-36; P?

SUBMITTER: Ross CE 

PROVIDER: S-EPMC6441975 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature