Ontology highlight
ABSTRACT:
SUBMITTER: Gilligan MM
PROVIDER: S-EPMC6442621 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Gilligan Molly M MM Gartung Allison A Sulciner Megan L ML Norris Paul C PC Sukhatme Vikas P VP Bielenberg Diane R DR Huang Sui S Kieran Mark W MW Serhan Charles N CN Panigrahy Dipak D
Proceedings of the National Academy of Sciences of the United States of America 20190312 13
Inflammation in the tumor microenvironment is a strong promoter of tumor growth. Substantial epidemiologic evidence suggests that aspirin, which suppresses inflammation, reduces the risk of cancer. The mechanism by which aspirin inhibits cancer has remained unclear, and toxicity has limited its clinical use. Aspirin not only blocks the biosynthesis of prostaglandins, but also stimulates the endogenous production of anti-inflammatory and proresolving mediators termed aspirin-triggered specialized ...[more]