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Gas/Liquid-Phase Micro-Flow Trifluoromethylation using Fluoroform: Trifluoromethylation of Aldehydes, Ketones, Chalcones, and N-Sulfinylimines.

ABSTRACT: A micro-flow nucleophilic trifluoromethylation of carbonyl compounds using gaseous fluoroform was developed. This method also allows the first micro-flow transformation of N-sulfinylimines into trifluoromethyl amines with excellent diastereoselectivity. To demonstrate the synthetic utility of this micro-flow synthesis, the formal micro-flow synthesis of Efavirenz is described.

SUBMITTER: Hirano K

PROVIDER: S-EPMC6442697 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Gas/Liquid-Phase Micro-Flow Trifluoromethylation using Fluoroform: Trifluoromethylation of Aldehydes, Ketones, Chalcones, and <i>N</i>-Sulfinylimines.

Hirano Kazuki K Gondo Satoshi S Punna Nagender N Tokunaga Etsuko E Shibata Norio N

ChemistryOpen 20190205 4

A micro-flow nucleophilic trifluoromethylation of carbonyl compounds using gaseous fluoroform was developed. This method also allows the first micro-flow transformation of <i>N</i>-sulfinylimines into trifluoromethyl amines with excellent diastereoselectivity. To demonstrate the synthetic utility of this micro-flow synthesis, the formal micro-flow synthesis of Efavirenz is described. ...[more]

PMID: 30976483

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