Ontology highlight
ABSTRACT:
SUBMITTER: Peng R
PROVIDER: S-EPMC6442729 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Peng Ruizi R Zheng Xiaofang X Lyu Yifan Y Xu Liujun L Zhang Xiaobing X Ke Guoliang G Liu Qiaoling Q You Changjun C Huan Shuangyan S Tan Weihong W
Journal of the American Chemical Society 20180725 31
Among the vast number of recognition molecules, DNA aptamers generated from cell-SELEX exhibit unique properties for identifying cell membrane biomarkers, in particular protein receptors on cancer cells. To integrate all recognition and computing modules within a single structure, a three-dimensional (3D) DNA-based logic gate nanomachine was constructed to target overexpressed cancer cell biomarkers with bispecific recognition. Thus, when the Boolean operator "AND" returns a true value, it is fo ...[more]