Ontology highlight
ABSTRACT:
SUBMITTER: Alwarawrah Y
PROVIDER: S-EPMC6443244 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Alwarawrah Yazan Y Hughes Philip P Loiselle David D Carlson David A DA Darr David B DB Jordan Jamie L JL Xiong Jessie J Hunter Lucas M LM Dubois Laura G LG Thompson J Will JW Kulkarni Manjusha M MM Ratcliff Annette N AN Kwiek Jesse J JJ Haystead Timothy A J TA
Cell chemical biology 20160602 6
Many tumors are dependent on de novo fatty acid synthesis to maintain cell growth. Fatty acid synthase (FASN) catalyzes the final synthetic step of this pathway, and its upregulation is correlated with tumor aggressiveness. The consequences and adaptive responses of acute or chronic inhibition of essential enzymes such as FASN are not fully understood. Herein we identify Fasnall, a thiophenopyrimidine selectively targeting FASN through its co-factor binding sites. Global lipidomics studies with ...[more]