IFN? PET Imaging as a Predictive Tool for Monitoring Response to Tumor Immunotherapy.
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ABSTRACT:
SUBMITTER: Gibson HM
PROVIDER: S-EPMC6443251 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
IFNγ PET Imaging as a Predictive Tool for Monitoring Response to Tumor Immunotherapy.
Gibson Heather M HM McKnight Brooke N BN Malysa Agnes A Dyson Greg G Wiesend Wendy N WN McCarthy Claire E CE Reyes Joyce J Wei Wei-Zen WZ Viola-Villegas Nerissa T NT
Cancer research 20180816 19
IFNγ is an attractive target for imaging active antitumor immunity due to its function in the T-cell signaling axis. Here, we test an IFNγ immuno-PET (immunoPET) probe for its capacity to identify adaptive immunotherapy response after HER2/neu vaccination in both spontaneous salivary and orthotopic neu<sup>+</sup> mouse mammary tumors. IFNγ immunoPET detected elevated cytokine levels <i>in situ</i> after vaccination, which inversely correlated with tumor growth rate, an indicator of response to ...[more]
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