Placental Growth Factor as an Indicator of Maternal Cardiovascular Risk After Pregnancy.

ABSTRACT:

Background

Angiogenic placental growth factor (PlGF) concentrations rise during pregnancy, peaking at the end of midpregnancy. Low PlGF concentrations during pregnancy are associated with pregnancy complications with recognized later-life cardiovascular risk. We hypothesized that low PlGF concentrations, especially in midpregnancy, identify not only a subset of women at risk for pregnancy complications but also women with greater cardiovascular risk factor burden after pregnancy regardless of pregnancy outcome.

Methods

In a population-based prospective cohort study of 5475 women, we computed gestational age-adjusted multiples of the medians of early pregnancy and midpregnancy PlGF concentrations. Information on pregnancy complications (preeclampsia, small for gestational age

SUBMITTER: Benschop L 

PROVIDER: S-EPMC6443459 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature