Dataset Information

Associations Between Cannabis Use and Cardiometabolic Risk Factors: A Longitudinal Study of Men.

ABSTRACT: OBJECTIVE:This study tested longitudinal associations between cannabis use and cardiometabolic risk factors that underlie the development of cardiovascular diseases. METHODS:Participants were men from the youngest cohort of the Pittsburgh Youth Study who were followed prospectively from approximately age 7 to 32 years (N = 253). Frequency of cannabis use was assessed yearly from approximately ages 12 to 20 years and again at approximately ages 26, 29, and 32 years. The following cardiometabolic risk factors were assessed during a laboratory visit at approximately age 32 years: body mass index (BMI), waist-hip ratio, high- and low-density lipoprotein cholesterol, triglycerides, fasting glucose, insulin resistance, blood pressure, interleukin 6, and C-reactive protein. RESULTS:Greater cannabis exposure was associated with relatively lower BMI (? = -0.31, p < .001), smaller waist-hip ratio (? = -0.23, p = .002), better high- (? = 0.14, p = .036) and low-density lipoprotein cholesterol (? = -0.15, p = .026), lower triglycerides (? = -0.17, p = .009), lower fasting glucose (? = -0.15, p < .001) and insulin resistance (? = -0.21, p = .003), lower systolic (? = -0.22, p < .001) and diastolic blood pressure (? = -0.15, p = .028), and fewer metabolic syndrome criteria (? = -0.27, p < .001). With exception of BMI, cannabis users' mean levels on cardiometabolic risk factors were generally below clinical cutoffs for high risk. Most associations between cannabis use and cardiometabolic risk factors remained after adjusting for tobacco use, childhood socioeconomic status, and childhood health. However, after adjusting for adult BMI, these associations were no longer apparent, and mediation tests suggested that cannabis users' relatively lower BMI might explain their lower levels of risk on other cardiometabolic risk factors. CONCLUSIONS:Cannabis use is associated with lower BMI, and lower BMI is related to lower levels of risk on other cardiometabolic risk factors.

SUBMITTER: Meier MH

PROVIDER: S-EPMC6443484 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Associations Between Cannabis Use and Cardiometabolic Risk Factors: A Longitudinal Study of Men.

Meier Madeline H MH Pardini Dustin D Beardslee Jordan J Matthews Karen A KA

Psychosomatic medicine 20190401 3

<h4>Objective</h4>This study tested longitudinal associations between cannabis use and cardiometabolic risk factors that underlie the development of cardiovascular diseases.<h4>Methods</h4>Participants were men from the youngest cohort of the Pittsburgh Youth Study who were followed prospectively from approximately age 7 to 32 years (N = 253). Frequency of cannabis use was assessed yearly from approximately ages 12 to 20 years and again at approximately ages 26, 29, and 32 years. The following c ...[more]

PMID: 30589665

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Project description:BACKGROUND AND AIMS:Few studies have explored how polygenic propensity to cannabis use unfolds across development, and no studies have yet examined this question in the context of environmental contributions such as peer cannabis use. Outlining the factors that contribute to progression from cannabis initiation to problem use over time may ultimately provide insights into mechanisms for targeted interventions. We sought to examine the relationships between polygenic liability for cannabis use, cannabis use trajectories from ages 12-30 years and perceived peer cannabis use at ages 12-17 years. DESIGN:Mixed-effect logistic and linear regressions were used to examine associations between polygenic risk scores, cannabis use trajectory membership and perceived peer cannabis use. SETTING:United States. PARTICIPANTS:From the Collaborative Study on the Genetics of Alcoholism (COGA) study, a cohort of 1167 individuals aged 12-26 years at their baseline (i.e. first) interview. MEASUREMENTS:Key measurements included life-time cannabis use (yes/no), frequency of past 12-month cannabis use, maximum life-time frequency of cannabis use, cannabis use disorder (using DSM-5 criteria) and perceived peer cannabis use. Polygenic risk scores (PRS) were created using summary statistics from a large (n = 162?082) genome-wide association study (GWAS) of cannabis use. FINDINGS:Three trajectories reflecting no/low (n = 844), moderate (n = 137) and high (n = 186) use were identified. PRS were significantly associated with trajectory membership [P = 0.002-0.006, maximum conditional R2 = 1.4%, odds ratios (ORs) = 1.40-1.49]. Individuals who reported that most/all of their best friends used cannabis had significantly higher PRS than those who reported that none of their friends were users [OR = 1.35, 95% confidence interval (CI) = 1.04, 1.75, P = 0.023]. Perceived peer use itself explained up to 11.3% of the variance in trajectory class membership (OR = 1.50-4.65). When peer cannabis use and the cannabis use PRS were entered into the model simultaneously, both the PRS and peer use continued to be significantly associated with class membership (P < 0.01). CONCLUSIONS:Genetic propensity to cannabis use derived from heterogeneous samples appears to correlate with longitudinal increases in cannabis use frequency in young adults.

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Dataset Information

Associations Between Cannabis Use and Cardiometabolic Risk Factors: A Longitudinal Study of Men.

Publications

Associations Between Cannabis Use and Cardiometabolic Risk Factors: A Longitudinal Study of Men.

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