Ontology highlight
ABSTRACT:
SUBMITTER: Balanco JMF
PROVIDER: S-EPMC6443866 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Balanco José Mário F JMF Sussmann Rodrigo A C RAC Verdaguer Ignasi B IB Gabriel Heloisa B HB Kimura Emilia A EA Katzin Alejandro M AM
FEBS open bio 20190305 4
Leishmaniasis is a neglected disease caused by a trypanosomatid protozoan of the genus <i>Leishmania</i>. Most drugs used to treat leishmaniasis are highly toxic, and the emergence of drug-resistant strains has been observed. Therefore, new therapeutic targets against leishmaniasis are required. Several isoprenoid compounds, including dolichols or ubiquinones, have been shown to be important for cell viability and proliferation in various trypanosomatid species. Here, we detected the biosynthesi ...[more]