Dataset Information

A New Metabolic Network Correlated with Olfactory and Executive Dysfunctions in Idiopathic Rapid Eye Movement Sleep Behavior Disorder.

ABSTRACT:

Background and purpose

To identify a metabolic network reflecting neurodegeneration in patients with idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD).

Methods

We recruited a prospective cohort comprising patients with de novo Parkinson's disease (PD) with probable REM sleep behavior disorder (PDRBD, n=21), polysomnography-confirmed iRBD patients (n=28), and age-matched healthy controls (HC) (n=24). PDRBD-related spatial covariance pattern (PDRBD-RP) were determined from ¹?F-fluorodeoxyglucose PET images of the PDRBD group and validated by reproduction in a separate PD cohort with polysomnography-confirmed REM sleep behavior disorder (n=11). We also confirmed via ¹?F-N-3-fluoropropyl-2?-carboxymethoxy-3?-(4-iodophenyl)-nortropane PET that none of our iRBD patients had any loss of dopamine transporters (DATs) suggestive of PD. Differences in the PDRBD-RP across groups were compared, and the clinical significance of these metabolic patterns in iRBD patients was further evaluated based on relationships with olfactory and cognitive functions, and striatal DAT densities.

Results

The PDRBD-RP reflected the previously reported PD-related covariance pattern and additionally showed relative metabolic increases in the hippocampus and premotor cortex. The PDRBD-RP gradually increased from the HC to iRBD patients and to the de novo and validation PDRBD groups. In iRBD patients, the PDRBD-RP was negatively correlated with olfactory and frontal executive functions (age-controlled p<0.01 for both), and tended to be negatively correlated with the striatal DAT density, although this was insignificant after age adjustment. During the mean follow-up period of 3.5 years, 5 of 11 iRBD patients with PDRBD-RP elevation had developed Lewy body diseases, whereas those without PDRBD-RP elevation had not.

Conclusions

Our results suggest that PDRBD-RP is an effective biomarker for monitoring the progression to neurodegenerative disease in iRBD patients.

SUBMITTER: Yoon EJ

PROVIDER: S-EPMC6444138 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Publications

A New Metabolic Network Correlated with Olfactory and Executive Dysfunctions in Idiopathic Rapid Eye Movement Sleep Behavior Disorder.

Yoon Eun Jin EJ Lee Jee Young JY Nam Hyunwoo H Kim Han Joon HJ Jeon Beomseok B Jeong Jae Min JM Kim Yu Kyeong YK

Journal of clinical neurology (Seoul, Korea) 20190311 2

<h4>Background and purpose</h4>To identify a metabolic network reflecting neurodegeneration in patients with idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD).<h4>Methods</h4>We recruited a prospective cohort comprising patients with <i>de novo</i> Parkinson's disease (PD) with probable REM sleep behavior disorder (PDRBD, <i>n</i>=21), polysomnography-confirmed iRBD patients (<i>n</i>=28), and age-matched healthy controls (HC) (<i>n</i>=24). PDRBD-related spatial covariance patt ...[more]

PMID: 30877691

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Dataset Information

A New Metabolic Network Correlated with Olfactory and Executive Dysfunctions in Idiopathic Rapid Eye Movement Sleep Behavior Disorder.

Background and purpose

Methods

Results

Conclusions

Publications

A New Metabolic Network Correlated with Olfactory and Executive Dysfunctions in Idiopathic Rapid Eye Movement Sleep Behavior Disorder.

Similar Datasets

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