Ontology highlight
ABSTRACT:
SUBMITTER: Hsu YP
PROVIDER: S-EPMC6444347 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Hsu Yen-Pang YP Hall Edward E Booher Garrett G Murphy Brennan B Radkov Atanas D AD Yablonowski Jacob J Mulcahey Caitlyn C Alvarez Laura L Cava Felipe F Brun Yves V YV Kuru Erkin E VanNieuwenhze Michael S MS
Nature chemistry 20190225 4
Peptidoglycan is an essential cell wall component that maintains the morphology and viability of nearly all bacteria. Its biosynthesis requires periplasmic transpeptidation reactions, which construct peptide crosslinkages between polysaccharide chains to endow mechanical strength. However, tracking the transpeptidation reaction in vivo and in vitro is challenging, mainly due to the lack of efficient, biocompatible probes. Here, we report the design, synthesis and application of rotor-fluorogenic ...[more]