Cost Analyses of Genomic Sequencing: Lessons Learned from the MedSeq Project.

ABSTRACT:

Objective

To summarize lessons learned while analyzing the costs of integrating whole genome sequencing into the care of cardiology and primary care patients in the MedSeq Project by conducting the first randomized controlled trial of whole genome sequencing in general and specialty medicine.

Methods

Case study that describes key methodological and data challenges that were encountered or are likely to emerge in future work, describes the pros and cons of approaches considered by the study team, and summarizes the solutions that were implemented.

Results

Major methodological challenges included defining whole genome sequencing, structuring an appropriate comparator, measuring downstream costs, and examining clinical outcomes. Discussions about solutions addressed conc

SUBMITTER: Christensen KD 

PROVIDER: S-EPMC6444358 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature