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Prognostic value of Lin28A and Lin28B in various human malignancies: a systematic review and meta-analysis.

ABSTRACT:

Background

The mammalian homologs of Lin-28, Lin28 (also called Lin28A) and Lin28B, are promising cancer biomarkers. This meta-analysis was performed to evaluate the prognostic values of Lin28A and Lin28B in multiple human malignancies.

Methods

Systematic searches of the PubMed, Web of Science and Embase were used to identify relevant studies. Pooled hazard ratios (HRs) with 95% confidence intervals (CI) for overall survival (OS), recurrence-free survival (RFS), disease-free survival (DFS), or progression-free survival (PFS) were respectively calculated.

Results

3772 Lin28A-associated patients and 1730 Lin28B-related cases were ultimately enrolled in this meta-analysis. The elevated expression level of Lin28A was significantly associated with poor OS (HR?=?1.60, P?ConclusionsLin28A and Lin28B possess significant prognostic values in various human malignancies. Overexpression of Lin28A or Lin28B suggests poor prognosis for cancer patients.

SUBMITTER: Zhang J

PROVIDER: S-EPMC6444518 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Prognostic value of Lin28A and Lin28B in various human malignancies: a systematic review and meta-analysis.

Zhang Jiayi J Xu Aiming A Miao Chenkui C Yang Jie J Gu Min M Song Ninghong N

Cancer cell international 20190402

<h4>Background</h4>The mammalian homologs of Lin-28, Lin28 (also called Lin28A) and Lin28B, are promising cancer biomarkers. This meta-analysis was performed to evaluate the prognostic values of Lin28A and Lin28B in multiple human malignancies.<h4>Methods</h4>Systematic searches of the PubMed, Web of Science and Embase were used to identify relevant studies. Pooled hazard ratios (HRs) with 95% confidence intervals (CI) for overall survival (OS), recurrence-free survival (RFS), disease-free survi ...[more]

PMID: 30976203

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