Ontology highlight
ABSTRACT:
SUBMITTER: Cho CC
PROVIDER: S-EPMC6445106 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Cho Chao-Cheng CC Chien Chia-Yu CY Chiu Yi-Chih YC Lin Meng-Hsuan MH Hsu Chun-Hua CH
Nature communications 20190402 1
Poly-ADP-ribosylation, a post-translational modification involved in various cellular processes, is well characterized in eukaryotes but thought to be devoid in bacteria. Here, we solve crystal structures of ADP-ribose-bound poly(ADP-ribose)glycohydrolase from the radioresistant bacterium Deinococcus radiodurans (DrPARG), revealing a solvent-accessible 2'-hydroxy group of ADP-ribose, which suggests that DrPARG may possess endo-glycohydrolase activity toward poly-ADP-ribose (PAR). We confirm the ...[more]