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Oxidation destabilizes toxic amyloid beta peptide aggregation.

ABSTRACT: The aggregation of insoluble amyloid beta (A?) peptides in the brain is known to trigger the onset of neurodegenerative diseases, such as Alzheimer's disease. In spite of the massive number of investigations, the underlying mechanisms to destabilize the A? aggregates are still poorly understood. Some studies indicate the importance of oxidation to destabilize the A? aggregates. In particular, oxidation induced by cold atmospheric plasma (CAP) has demonstrated promising results in eliminating these toxic aggregates. In this paper, we investigate the effect of oxidation on the stability of an A? pentamer. By means of molecular dynamics simulations and umbrella sampling, we elucidate the conformational changes of A? pentamer in the presence of oxidized residues, and we estimate the dissociation free energy of the terminal peptide out of the pentamer form. The calculated dissociation free energy of the terminal peptide is also found to decrease with increasing oxidation. This indicates that A? pentamer aggregation becomes less favorable upon oxidation. Our study contributes to a better insight in one of the potential mechanisms for inhibition of toxic A? peptide aggregation, which is considered to be the main culprit to Alzheimer's disease.

SUBMITTER: Razzokov J

PROVIDER: S-EPMC6445117 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Oxidation destabilizes toxic amyloid beta peptide aggregation.

Razzokov J J Yusupov M M Bogaerts A A

Scientific reports 20190402 1

The aggregation of insoluble amyloid beta (Aβ) peptides in the brain is known to trigger the onset of neurodegenerative diseases, such as Alzheimer's disease. In spite of the massive number of investigations, the underlying mechanisms to destabilize the Aβ aggregates are still poorly understood. Some studies indicate the importance of oxidation to destabilize the Aβ aggregates. In particular, oxidation induced by cold atmospheric plasma (CAP) has demonstrated promising results in eliminating the ...[more]

PMID: 30940901

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Oxidation destabilizes toxic amyloid beta peptide aggregation.

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Oxidation destabilizes toxic amyloid beta peptide aggregation.

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