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Molecular characterization and epidemiology of Streptococcus pneumoniae serotype 24F in Denmark.


ABSTRACT: Since 2012, have we in Denmark observed an increase of invasive pneumococcal infections (IPD) due to Streptococcus pneumoniae serotype 24F. We here present epidemiological data on 24F IPD cases, and characterization of 48 24F clinical isolates based on clonal relationship, antimicrobial resistance (AMR) determinants and virulence factors. IPD surveillance data from (1999-2016) were used to calculate the incidence and age-distribution of serotype 24F IPD and the effect of pneumococcal conjugated vaccines (PCV). Characterization of forty-eight 24F isolates (14.7% of all 24F isolates from the period) was based on whole-genome sequencing analysis (WGS). The IPD cases of serotype 24F showed a significant increase (p?

SUBMITTER: Kavalari ID 

PROVIDER: S-EPMC6445336 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Molecular characterization and epidemiology of Streptococcus pneumoniae serotype 24F in Denmark.

Kavalari Ioanna Drakaki ID   Fuursted Kurt K   Krogfelt Karen A KA   Slotved H-C HC  

Scientific reports 20190402 1


Since 2012, have we in Denmark observed an increase of invasive pneumococcal infections (IPD) due to Streptococcus pneumoniae serotype 24F. We here present epidemiological data on 24F IPD cases, and characterization of 48 24F clinical isolates based on clonal relationship, antimicrobial resistance (AMR) determinants and virulence factors. IPD surveillance data from (1999-2016) were used to calculate the incidence and age-distribution of serotype 24F IPD and the effect of pneumococcal conjugated  ...[more]

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