Dataset Information

Correlation between spot and 24h proteinuria: Derivation and validation of equation to estimate daily proteinuria.

ABSTRACT: Daily urine protein (UP) loss is a cumbersome but important measurement to guide diagnosis and treatment of renal disease. Spot urine protein-creatinine ratio (UPCR) can been applied to estimate daily proteinuria. However, the correlations between spot and 24h proteinuria remain controversial. In this cross-sectional study, simultaneous collection of 24h and spot urines were performed from 1,039 (derivation cohort) and 204 CKD patients (validation cohort) of Chang Gung Memorial Hospital, from 2007 to 2017. The correlations between spot UPCR and 24h proteinuria were compared. The mean age of patients of derivation and validation cohort was 63 and 55 years and the mean estimated glomerular filtration rate was 62 ± 35 and 59 ± 36 mL/min/m2, respectively. The correlation coefficient was 0.819 between UPCR and 24hUP. Prediction equation was derived as: Log1024hUP (g) = 0.814 x Log10UPCR (mg/mg) + 0.110 x Gender- 0.004 x Age + 0.004 x Body weight (kg) + 0.002 x CKD stage coefficient- 0.018, where CKD stage coefficient: CKD stage G1 = 1, G2 = 2, G3a = 3.1, G3b = 3.2, G4 = 4, G5 = 5. Correlation coefficient between measured and predicted 24hUP among derivation group and validation group is 0.866 and 0.915, respectively. However, the agreement of spot and daily estimates was less pronounced with proteinuria > 3g than lower values in Bland-Altman analysis. Spot UPCR can accurately predict 24hUP in patients with daily proteinuria below 3g. The development of this equation may facilitate estimation of 24hUP in the clinical practice.

SUBMITTER: Chen YT

PROVIDER: S-EPMC6445407 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Correlation between spot and 24h proteinuria: Derivation and validation of equation to estimate daily proteinuria.

Chen Yih-Ting YT Hsu Heng-Jung HJ Hsu Cheng-Kai CK Lee Chin-Chan CC Hsu Kuang-Hung KH Sun Chiao-Yin CY Chen Chun-Yu CY Chen Yung-Chang YC Yu Yi-Ching YC Wu I-Wen IW

PloS one 20190402 4

Daily urine protein (UP) loss is a cumbersome but important measurement to guide diagnosis and treatment of renal disease. Spot urine protein-creatinine ratio (UPCR) can been applied to estimate daily proteinuria. However, the correlations between spot and 24h proteinuria remain controversial. In this cross-sectional study, simultaneous collection of 24h and spot urines were performed from 1,039 (derivation cohort) and 204 CKD patients (validation cohort) of Chang Gung Memorial Hospital, from 20 ...[more]

PMID: 30939176

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Correlation between spot and 24h proteinuria: Derivation and validation of equation to estimate daily proteinuria.

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Correlation between spot and 24h proteinuria: Derivation and validation of equation to estimate daily proteinuria.

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