Ontology highlight
ABSTRACT:
SUBMITTER: Zietzer A
PROVIDER: S-EPMC6445437 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Zietzer Andreas A Niepmann Sven Thomas ST Camara Bakary B Lenart Monika Anna MA Jansen Felix F Becher Marc Ulrich MU Andrié René R Nickenig Georg G Tiyerili Vedat V
PloS one 20190402 4
<h4>Introduction</h4>Atherosclerotic plaque formation is an inflammatory process that involves the recruitment of neutrophil granulocytes and the generation of reactive oxygen species (ROS). ROS formation by myeloperoxidase, a key enzyme in H2O2 degradation, can be modulated by addition of sodium thiocyanate (NaSCN). However, the therapeutic use of NaSCN to counteract atherogenesis has been controversial, because MPO oxidizes NaSCN to hypothiocyanous acid, which is a reactive oxygen species itse ...[more]