Ontology highlight
ABSTRACT:
SUBMITTER: Dunn JT
PROVIDER: S-EPMC6445483 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Dunn Joel T JT Choudhary Pratik P Teh Ming Ming MM Macdonald Ian I Hunt Katharine F KF Marsden Paul K PK Amiel Stephanie A SA
Diabetologia 20180512 7
<h4>Aims/hypothesis</h4>Impaired awareness of hypoglycaemia (IAH) in type 1 diabetes increases the risk of severe hypoglycaemia sixfold and can be resistant to intervention. We explored the impact of IAH on central responses to hypoglycaemia to investigate the mechanisms underlying barriers to therapeutic intervention.<h4>Methods</h4>We conducted [<sup>15</sup>O]water positron emission tomography studies of regional brain perfusion during euglycaemia (target 5 mmol/l), hypoglycaemia (achieved le ...[more]