Ontology highlight
ABSTRACT:
SUBMITTER: Bird P
PROVIDER: S-EPMC6445596 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Bird Paul P Bensen William W El-Zorkany Bassel B Kaine Jeffrey J Manapat-Reyes Bernadette Heizel BH Pascual-Ramos Virginia V Witcombe David D Soma Koshika K Zhang Richard R Thirunavukkarasu Krishan K
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 20190401 3
<h4>Background</h4>Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We performed a comprehensive review of phase 3 studies of tofacitinib 5 mg twice daily (BID) (approved dose in many countries) in patients with moderate to severe RA and inadequate response to prior disease-modifying antirheumatic drugs.<h4>Methods</h4>A search of PubMed and ClinicalTrials.gov identified 5 studies: ORAL Solo (NCT00814307), ORAL Sync (NCT00856544), ORAL Standard (inclu ...[more]