Dataset Information

Maternal residential exposure to specific agricultural pesticide active ingredients and birth defects in a 2003-2005 North Carolina birth cohort.

ABSTRACT:

Background

Previously we observed elevated odds ratios (ORs) for total pesticide exposure and 10 birth defects: three congenital heart defects and structural defects affecting the gastrointestinal, genitourinary and musculoskeletal systems. This analysis examines association of those defects with exposure to seven commonly applied pesticide active ingredients.

Methods

Cases were live-born singleton infants from the North Carolina Birth Defects Monitoring Program linked to birth records for 2003-2005; noncases served as controls (total n = 304,906). Pesticide active ingredient exposure was assigned using a previously constructed metric based on crops within 500 m of residence, dates of pregnancy, and likely chemical application dates for each pesticide-crop combination. ORs (95% CI) were estimated with logistic regression for categories of exposure compared to unexposed. Models were adjusted for maternal race/ethnicity, age at delivery, education, marital status, and smoking status.

Results

Associations varied by birth defect and pesticide combinations. For example, hypospadias was positively associated with exposures to 2,4-D (OR_{50th to <90th percentile} : 1.39 [1.18, 1.64]), mepiquat (OR_{50th to <90th percentile} : 1.10 [0.90, 1.34]), paraquat (OR_{50th to <90th} : 1.14 [0.93, 1.39]), and pendimethalin (OR_{50th to <90th} : 1.21 [1.01, 1.44]), but not S-metolachlor (OR_{50th to <90th} : 1.00 [0.81, 1.22]). Whereas atrial septal defects were positively associated with higher levels of exposure to glyphosate, cyhalothrin, S-metolachlor, mepiquat, and pendimethalin (ORs ranged from 1.22 to 1.35 for 50th to <90th exposures, and 1.72 to 2.09 for >90th exposures); associations with paraquat were null or inconsistent (OR 50th to <90th: 1.05 (0.87, 1.27).

Conclusion

Our results suggest differing patterns of association for birth defects with residential exposure to seven pesticide active ingredients in North Carolina.

SUBMITTER: Rappazzo KM

PROVIDER: S-EPMC6445756 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Publications

Maternal residential exposure to specific agricultural pesticide active ingredients and birth defects in a 2003-2005 North Carolina birth cohort.

Rappazzo Kristen M KM Warren Joshua L JL Davalos Angel D AD Meyer Robert E RE Sanders Alison P AP Brownstein Naomi C NC Luben Thomas J TJ

Birth defects research 20181228 6

<h4>Background</h4>Previously we observed elevated odds ratios (ORs) for total pesticide exposure and 10 birth defects: three congenital heart defects and structural defects affecting the gastrointestinal, genitourinary and musculoskeletal systems. This analysis examines association of those defects with exposure to seven commonly applied pesticide active ingredients.<h4>Methods</h4>Cases were live-born singleton infants from the North Carolina Birth Defects Monitoring Program linked to birth re ...[more]

PMID: 30592382

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Dataset Information

Maternal residential exposure to specific agricultural pesticide active ingredients and birth defects in a 2003-2005 North Carolina birth cohort.

Background

Methods

Results

Conclusion

Publications

Maternal residential exposure to specific agricultural pesticide active ingredients and birth defects in a 2003-2005 North Carolina birth cohort.

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