Ontology highlight
ABSTRACT:
SUBMITTER: Liu H
PROVIDER: S-EPMC6446192 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
EMBO reports 20190314 4
Cyclic dinucleotides (CDNs) are important second messenger molecules in prokaryotes and eukaryotes. Within host cells, cytosolic CDNs are detected by STING and alert the host by activating innate immunity characterized by type I interferon (IFN) responses. Extracellular bacteria and dying cells can release CDNs, but sensing of extracellular CDNs (eCDNs) by mammalian cells remains elusive. Here, we report that endocytosis facilitates internalization of eCDNs. The DNA sensor cGAS facilitates sensi ...[more]