Dataset Information

No association between Parkinson disease and autoantibodies against NMDA-type glutamate receptors.

ABSTRACT:

Background

IgG-class autoantibodies to N-Methyl-D-Aspartate (NMDA)-type glutamate receptors define a novel entity of autoimmune encephalitis. Studies examining the prevalence of NMDA IgA/IgM antibodies in patients with Parkinson disease with/without dementia produced conflicting results. We measured NMDA antibodies in a large, well phenotyped sample of Parkinson patients without and with cognitive impairment (n =?296) and controls (n =?295) free of neuropsychiatric disease. Detailed phenotyping and large numbers allowed statistically meaningful correlation of antibody status with diagnostic subgroups as well as quantitative indicators of disease severity and cognitive impairment.

Methods

NMDA antibodies were analysed in the serum of patients and controls using well established validated assays. We used anti-NMDA antibody positivity as the main independent variable and correlated it with disease status and phenotypic characteristics.

Results

The frequency of NMDA IgA/IgM antibodies was lower in Parkinson patients (13%) than in controls (22%) and higher than in previous studies in both groups. NMDA IgA/IgM antibodies were neither significantly associated with diagnostic subclasses of Parkinson disease according to cognitive impairment, nor with quantitative indicators of disease severity and cognitive impairment. A positive NMDA antibody status was positively correlated with age in controls but not in Parkinson patients.

Conclusion

It is unlikely albeit not impossible that NMDA antibodies play a significant role in the pathogenesis or progression of Parkinson disease e.g. to Parkinson disease with dementia, while NMDA IgG antibodies define a separate disease of its own.

SUBMITTER: Hopfner F

PROVIDER: S-EPMC6446289 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Publications

No association between Parkinson disease and autoantibodies against NMDA-type glutamate receptors.

Hopfner Franziska F Müller Stefanie H SH Steppat Dagmar D Miller Joanna J Schmidt Nele N Wandinger Klaus-Peter KP Leypoldt Frank F Berg Daniela D Franke Andre A Lieb Wolfgang W Tittmann Lukas L Balzer-Geldsetzer Monika M Baudrexel Simon S Dodel Richard R Hilker-Roggendorf Ruediger R Kalbe Elke E Kassubek Jan J Klockgether Thomas T Liepelt-Scarfone Inga I Mollenhauer Brit B Neuser Petra P Reetz Kathrin K Riedel Oliver O Schulte Claudia C Schulz Jörg B JB Spottke Annika A Storch Alexander A Trenkwalder Claudia C Wittchen Hans-Ulrich HU Witt Karsten K Wüllner Ullrich U Deuschl Günther G Kuhlenbäumer Gregor G

Translational neurodegeneration 20190403

<h4>Background</h4>IgG-class autoantibodies to N-Methyl-D-Aspartate (NMDA)-type glutamate receptors define a novel entity of autoimmune encephalitis. Studies examining the prevalence of NMDA IgA/IgM antibodies in patients with Parkinson disease with/without dementia produced conflicting results. We measured NMDA antibodies in a large, well phenotyped sample of Parkinson patients without and with cognitive impairment (<i>n</i> = 296) and controls (<i>n</i> = 295) free of neuropsychiatric disease. ...[more]

PMID: 30984390

Similar Datasets

Project description:BACKGROUND: Recent data from neuroimaging, genetic and clinical trials and animal models suggest a role for altered glutamatergic neuro transmission in the pathogenesis of obsessive-compulsive disorder (OCD). The aim of this study was to investigate whether variants in the GRIN2B gene, the gene encoding the NR2 subunit of the N-methyl-D-aspartate (NMDA) glutamate receptor, may contribute to genetic susceptibility to OCD or to different OCD subphenotypes. METHODS: Between 2003 and 2008, we performed a case-control association study in which we genotyped 10 tag single-nucleotide polymorphisms (SNPs) in the 3' untranslated region (3' UTR) of GRIN2B. We performed SNP association and haplotype analysis considering the OCD diagnosis and different OCD subphenotypes: early-onset OCD, comorbid tic disorders and OCD clinical symptom dimensions. RESULTS: We enrolled 225 patients with OCD and 279 controls recruited from the OCD Clinic at Bellvitge Hospital (Barcelona, Spain). No significant difference in the distribution of alleles or genotypes was detected between patients with OCD and controls. Nonetheless, on analyzing OCD subphenotypes, the rs1805476 SNP in male patients (95% confidence interval [CI] 1.37-4.22, p = 0.002) and a 4-SNP haplotype in the whole sample (rs1805476, rs1805501, rs1805502 and rs1805477; odds ratio 1.92, 95% CI 1.22-3.01; permutation p = 0.023) were significantly associated with the presence of contamination obsessions and cleaning compulsions. LIMITATIONS: Study limitations included the risk of population stratification associated with the case-control design, use of psychiatrically unscreened blood donors as the control group, reduced sample size of participants with certain OCD subphenotypes and tested polymorphisms limited to 3' UTR and exon 13 of GRIN2B. CONCLUSION: Our results converge with recent data suggesting a possible contribution of glutamatergic variants to the genetic vulnerability to OCD or at least to certain OCD manifestations. The dissection of OCD into more homogeneous subphenotypes may constitute a useful tool to disentangle the complex genetic basis of the disorder.

Dataset Information

No association between Parkinson disease and autoantibodies against NMDA-type glutamate receptors.

Background

Methods

Results

Conclusion

Publications

No association between Parkinson disease and autoantibodies against NMDA-type glutamate receptors.

Similar Datasets

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