Transcriptionally promiscuous "blurry" promoters in Tc1/mariner transposons allow transcription in distantly related genomes.
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ABSTRACT:
SUBMITTER: Palazzo A
PROVIDER: S-EPMC6446368 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Transcriptionally promiscuous "blurry" promoters in Tc1/<i>mariner</i> transposons allow transcription in distantly related genomes.
Palazzo Antonio A Lorusso Patrizio P Miskey Csaba C Walisko Oliver O Gerbino Andrea A Marobbio Carlo Marya Thomas CMT Ivics Zoltán Z Marsano René Massimiliano RM
Mobile DNA 20190403
<h4>Background</h4>We have recently described a peculiar feature of the promoters in two <i>Drosophila Tc1</i>-like elements, <i>Bari1</i> and <i>Bari3</i>. The AT-richness and the presence of weak core-promoter motifs make these promoters, that we have defined "blurry", able to activate transcription of a reporter gene in cellular systems as diverse as fly, human, yeast and bacteria. In order to clarify whether the blurry promoter is a specific feature of the <i>Bari</i> transposon family, we h ...[more]
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