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A Bioelectronic Platform Modulates pH in Biologically Relevant Conditions.

ABSTRACT: Bioelectronic devices that modulate pH can affect critical biological processes including enzymatic activity, oxidative phosphorylation, and neuronal excitability. A major challenge in controlling pH is the high buffering capacity of many biological media. To overcome this challenge, devices need to be able to store and deliver a large number of protons on demand. Here, a bioelectronic modulator that controls pH using palladium nanoparticles contacts with high surface area as a proton storage medium is developed. Reversible electronically triggered acidosis (low pH) and alkalosis (high pH) in physiologically relevant buffer conditions are achieved. As a proof of principle, this new platform is used to control the degradation and fluorescence of acid sensitive polymeric microparticles loaded with a pH sensitive fluorescent dye.

SUBMITTER: Strakosas X

PROVIDER: S-EPMC6446605 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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A Bioelectronic Platform Modulates pH in Biologically Relevant Conditions.

Strakosas Xenofon X Selberg John J Zhang Xiaolin X Christie Noah N Hsu Peng-Hao PH Almutairi Adah A Rolandi Marco M

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20190128 7

Bioelectronic devices that modulate pH can affect critical biological processes including enzymatic activity, oxidative phosphorylation, and neuronal excitability. A major challenge in controlling pH is the high buffering capacity of many biological media. To overcome this challenge, devices need to be able to store and deliver a large number of protons on demand. Here, a bioelectronic modulator that controls pH using palladium nanoparticles contacts with high surface area as a proton storage me ...[more]

PMID: 30989015

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