Polymorphic Analysis of Leptin Promoter in Obese/diabetic Subjects in Kashmiri Population.

ABSTRACT:

Background

The role of common variants in leptin promoter has already been established to play a major role in obesity and diabetes in humans. The study was accordingly focused on leptin promoter variants and their potential association with diabetes and obesity in ethnic population from Kashmir, India.

Methods

Allele frequencies of 620 Kashmiri subjects with diabetes (200), obese subjects (200), and ethnically matched healthy controls (200) were tested for the Hardy-Weinberg disequilibrium. Among 200 obese subjects, a total of 50 persons were with diabetes. The genotype and allele frequencies were evaluated using the Chi-square or Fisher's exact tests.

Results

Sequence analysis revealed two reported variations i.e., rs72563764C>T and rs7799039G>A in promoter region.

SUBMITTER: Dar R 

PROVIDER: S-EPMC6446689 | biostudies-literature | 2019 Jan-Feb

REPOSITORIES: biostudies-literature