Biliary tract cancers: current knowledge, clinical candidates and future challenges.
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ABSTRACT:
SUBMITTER: Tariq NU
PROVIDER: S-EPMC6446989 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Biliary tract cancers: current knowledge, clinical candidates and future challenges.
Tariq Noor-Ul-Ain NU McNamara Mairéad G MG Valle Juan W JW
Cancer management and research 20190329
Biliary tract cancers (BTCs) are rare with poor prognosis. Due to the advent of genomic sequencing, new data have emerged regarding the molecular makeup of this disease. To add to the complexity, various subtypes also harbor a varied genetic composition. The commonly mutated genes associated with this cancer are <i>KRAS</i>, <i>EGFR</i>, <i>IDH</i>, <i>FGFR</i> and <i>BAP1</i>. Various clinical studies are looking at targeting these genetic mutations. Another therapeutic area of note is the pote ...[more]
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