Browse
Submit Data
Databases
API
Help

Dataset Information

15 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Bioinspired Artificial Nanodecoys for Hepatitis?B Virus.

ABSTRACT: A facile route is presented for fabricating a new class of nanomimics that overexpress hepatitis B virus (HBV) receptor by a natural biosynthetic procedure against HBV infection. A nine-transmembrane HBV-specific receptor, human sodium taurocholate co-transporting polypeptide (hNTCP), was engineered to naturally immobilize it onto the cellular surface and subsequently trigger the budding of hNTCP-anchoring membrane vesicles (hNTCP-MVs) that favor the HBV virion. hNTCP-MVs could rapidly block HBV infection in cell models. Furthermore, hNTCP-MVs treatment could effectively prevent viral infection, spreading, and replication in a human-liver-chimeric mouse model of HBV infection. Our findings demonstrate the receptor-mediated antiviral effect of hNTCP-MVs to trick HBV and offer novel opportunities for further development of antiviral strategies in nanomedicine.

SUBMITTER: Liu X

PROVIDER: S-EPMC6447037 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

Bioinspired Artificial Nanodecoys for Hepatitis B Virus.

Liu Xuan X Yuan Lunzhi L Zhang Liang L Mu Yalin Y Li Xiaoling X Liu Chao C Lv Peng P Zhang Yali Y Cheng Tong T Yuan Quan Q Xia Ningshao N Chen Xiaoyuan X Liu Gang G

Angewandte Chemie (International ed. in English) 20180823 38

A facile route is presented for fabricating a new class of nanomimics that overexpress hepatitis B virus (HBV) receptor by a natural biosynthetic procedure against HBV infection. A nine-transmembrane HBV-specific receptor, human sodium taurocholate co-transporting polypeptide (hNTCP), was engineered to naturally immobilize it onto the cellular surface and subsequently trigger the budding of hNTCP-anchoring membrane vesicles (hNTCP-MVs) that favor the HBV virion. hNTCP-MVs could rapidly block HBV ...[more]

PMID: 30088325

Similar Datasets

Bioinspired methodology for artificial olfaction.

Project description:Artificial olfaction is a potential tool for noninvasive chemical monitoring. Application of "electronic noses" typically involves recognition of "pretrained" chemicals, while long-term operation and generalization of training to allow chemical classification of "unknown" analytes remain challenges. The latter analytical capability is critically important, as it is unfeasible to pre-expose the sensor to every analyte it might encounter. Here, we demonstrate a biologically inspired approach where the recognition and generalization problems are decoupled and resolved in a hierarchical fashion. Analyte composition is refined in a progression from general (e.g., target is a hydrocarbon) to precise (e.g., target is ethane), using highly optimized response features for each step. We validate this approach using a MEMS-based chemiresistive microsensor array. We show that this approach, a unique departure from existing methodologies in artificial olfaction, allows the recognition module to better mitigate sensor-aging effects and to better classify unknowns, enhancing the utility of chemical sensors for real-world applications.

| S-EPMC2583168 | biostudies-literature

A bioinspired analogous nerve towards artificial intelligence.

Project description:A bionic artificial device commonly integrates various distributed functional units to mimic the functions of biological sensory neural system, bringing intricate interconnections, complicated structure, and interference in signal transmission. Here we show an all-in-one bionic artificial nerve based on a separate electrical double-layers structure that integrates the functions of perception, recognition, and transmission. The bionic artificial nerve features flexibility, rapid response (<21?ms), high robustness, excellent durability (>10,000 tests), personalized cutability, and no energy consumption when no mechanical stimulation is being applied. The response signals are highly regionally differentiated for the mechanical stimulations, which enables the bionic artificial nerve to mimic the spatiotemporally dynamic logic of a biological neural network. Multifunctional touch interactions demonstrate the enormous potential of the bionic artificial nerve for human-machine hybrid perceptual enhancement. By incorporating the spatiotemporal resolution function and algorithmic analysis, we hope that bionic artificial nerves will promote further development of sophisticated neuroprosthetics and intelligent robotics.

| S-EPMC6959309 | biostudies-literature

Bioinspired artificial platelets: past, present and future.

Project description:Platelets are anucleate blood cells produced from megakaryocytes predominantly in the bone marrow and released into blood circulation at a healthy count of 150,000-400,00 per μL and circulation lifespan of 7-9 days. Platelets are the first responders at the site of vascular injury and bleeding, and participate in clot formation via injury site-specific primary mechanisms of adhesion, activation and aggregation to form a platelet plug, as well as secondary mechanisms of augmenting coagulation via thrombin amplification and fibrin generation. Platelets also secrete various granule contents that enhance these mechanisms for clot growth and stability. The resultant clot seals the injury site to stanch bleeding, a process termed as hemostasis. Due to this critical role, a reduction in platelet count or dysregulation in platelet function is associated with bleeding risks and hemorrhagic complications. These scenarios are often treated by prophylactic or emergency transfusion of platelets. However, platelet transfusions face significant challenges due to limited donor availability, difficult portability and storage, high bacterial contamination risks, and very short shelf life (~5-7 days). These are currently being addressed by a robust volume of research involving reduced temperature storage and pathogen reduction processes on donor platelets to improve shelf-life and reduce contamination, as well as bioreactor-based approaches to generate donor-independent platelets from stem cells in vitro. In parallel, a complementary research field has emerged that involves the design of artificial platelets utilizing biosynthetic particle constructs that functionally emulate various hemostatic mechanisms of platelets. Here, we provide a comprehensive review of the history and the current state-of-the-art artificial platelet approaches, along with discussing the translational opportunities and challenges.

| S-EPMC8795470 | biostudies-literature

Bioinspired soft electroreceptors for artificial precontact somatosensation.

Project description:Artificial haptic sensors form the basis of touch-based human-interfaced applications. However, they are unable to respond to remote events before physical contact. Some elasmobranch fishes, such as seawater sharks, use electroreception somatosensory system for remote environmental perception. Inspired by this ability, we design a soft artificial electroreceptor for sensing approaching targets. The electroreceptor, enabled by an elastomeric electret, is capable of encoding environmental precontact information into a series of voltage pulses functioning as unique precontact human interfaces. Electroceptor applications are demonstrated in a prewarning system, robotic control, game operation, and three-dimensional object recognition. These capabilities in perceiving proximal precontact events can lenrich the functionalities and applications of human-interfaced electronics.

| S-EPMC9140963 | biostudies-literature

Bioinspired Suprahelical Frameworks as Scaffolds for Artificial Photosynthesis.

Project description:Framework materials have shown promising potential in various biological applications. However, the state-of-the-art components show low biocompatibility or mechanical instability, or cannot integrate both optics and electronics, thus severely limiting their extensive applications in biological systems. Herein, we demonstrate that amide-based bioorganic building blocks, including dipeptides and dipeptide nucleic acids, can self-assemble into hydrogen-bonded suprahelix architectures of controllable handedness, which then form suprahelical frameworks with diverse cavities. Especially, the cavities can be tuned to be hydrophilic or hydrophobic, and the shortest diagonal distance can be modulated from 0.5 to 1.8 nm, with the volume proportion in the unit cell changing from 5 to 60%. Furthermore, the hydrogen bonding networks result in high mechanical rigidity and semiconductively optoelectronic properties, which allow the utilization of the suprahelical frameworks as supramolecular scaffolds for artificial photosynthesis. Our findings reveal amide-based suprahelix architectures acting as bioinspired supramolecular frameworks, thus extending the constituents portfolio and increasing the feasibility of using framework materials for biological applications.

| S-EPMC7549093 | biostudies-literature

Bioinspired synthesis of SnO crosses as backbone in artificial sponges.

Project description:The distinct electronic properties, including p-type semiconducting and a wide optical band gap, renders SnO suitable for applications such as microelectronic devices, gas sensors and electrodes. However, the synthesis of SnO is rather challenging due to the instability of the oxide, which is usually obtained as a by-product of SnO2 fabrication. In this work, we developed a bioinspired synthesis, based on a hydrothermal approach, for the direct production of SnO nanoparticles. The amount of mineralizer, inducing the precipitation, was identified, which supports a template-free formation of the nanosized SnO particles at low temperature and mild chemical conditions. Moreover, the SnO nanoparticles exhibit a shape of unique three-dimensional crosses similar to the calcite crosses present in the calcareous sponges. We demonstrated that SnO crosses are evenly distributed and embedded in an organic scaffold by an ice-templating approach, in this way closely mimicking the structure of calcareous sponges. Such scaffolds, reinforced by an active material, here SnO, could be used as filters, sensors or electrodes, where a high surface area and good accessibility are essential. This article is part of the theme issue 'Bioinspired materials and surfaces for green science and technology (part 2)'.

| S-EPMC6562352 | biostudies-literature

Bioinspired mechano-photonic artificial synapse based on graphene/MoS2 heterostructure.

Project description:Developing multifunctional and diversified artificial neural systems to integrate multimodal plasticity, memory, and supervised learning functions is an important task toward the emulation of neuromorphic computation. Here, we present a bioinspired mechano-photonic artificial synapse with synergistic mechanical and optical plasticity. The artificial synapse is composed of an optoelectronic transistor based on graphene/MoS2 heterostructure and an integrated triboelectric nanogenerator. By controlling the charge transfer/exchange in the heterostructure with triboelectric potential, the optoelectronic synaptic behaviors can be readily modulated, including postsynaptic photocurrents, persistent photoconductivity, and photosensitivity. The photonic synaptic plasticity is elaborately investigated under the synergistic effect of mechanical displacement and the light pulses embodying different spatiotemporal information. Furthermore, artificial neural networks are simulated to demonstrate the improved image recognition accuracy up to 92% assisted with mechanical plasticization. The mechano-photonic artificial synapse is highly promising for implementing mixed-modal interaction, emulating complex biological nervous system, and promoting the development of interactive artificial intelligence.

| S-EPMC7968845 | biostudies-literature

A bioinspired optoelectronically engineered artificial neurorobotics device with sensorimotor functionalities.

Project description:Development of the next generation of bio- and nano-electronics is inseparably connected to the innovative concept of emulation and reproduction of biological sensorimotor systems and artificial neurobotics. Here, we report for the first time principally new artificial bioinspired optoelectronic sensorimotor system for the controlable immitation of opto-genetically engineered neurons in the biological motor system. The device is based on inorganic optical synapse (In-doped TiO2 nanofilm) assembled into a liquid metal (galinstan) actuator. The optoelectronic synapse generates polarised excitatory and inhibitory postsynaptic potentials to trigger the liquid metal droplet to vibrate and then mimic the expansion and contraction of biological fibre muscle. The low-energy consumption and precise modulation of electrical and mechanical outputs are the distinguished characteristics of fabricated sensorimotor system. This work is the underlying significant step towards the development of next generation of low-energy the internet of things for bioinspired neurorobotic and bioelectronic system.

| S-EPMC6712026 | biostudies-literature

A soft, bioinspired artificial lymphatic system for interactive ascites transfer.

Project description:Low-flow removal of refractory ascites is critical to treating cirrhosis and digestive system tumor, and thus, commercial ascites pump emerged lately. The rigid structure of clinically available pumps rises complication rate and lack of flow rate monitoring hinders early warning of abnormalities. Herein, a soft artificial system was proposed inspired by lymph for interactive ascites transfer with great biocompatibility. The implantable system is composed of pump cavity, valves and tubes, which are soft and flexible made by silica gel. Therefore, the system possesses similar modulus to tissues and can naturally fit surrounding tissues. The cavity with magnetic tablet embedded is driven by extracorporeal magnetic field. Subsequently, the system can drain ascites with a top speed of 23 mL min-1, much higher than that of natural lymphatic system and state-of-art devices. Moreover, integrated flexible sensors enable wireless, real-time flow rate monitoring, serving as proof of treatment adjustment, detection and locating of malfunction at early stage. The liver function of experimental objects was improved, and no severe complications occurred for 4 weeks, which proved its safety and benefit to treatment. This artificial lymphatic system can serve as a bridge to recovery and pave the way for further clinical research.

| S-EPMC10486333 | biostudies-literature

Artificial eye for scotopic vision with bioinspired all-optical photosensitivity enhancer.

Project description:The ability to acquire images under low-light conditions is critical for many applications. However, to date, strategies toward improving low-light imaging primarily focus on developing electronic image sensors. Inspired by natural scotopic visual systems, we adopt an all-optical method to significantly improve the overall photosensitivity of imaging systems. Such optical approach is independent of, and can effectively circumvent the physical and material limitations of, the electronics imagers used. We demonstrate an artificial eye inspired by superposition compound eyes and the retinal structure of elephantnose fish. The bioinspired photosensitivity enhancer (BPE) that we have developed enhances the image intensity without consuming power, which is achieved by three-dimensional, omnidirectionally aligned microphotocollectors with parabolic reflective sidewalls. Our work opens up a previously unidentified direction toward achieving high photosensitivity in imaging systems.

| S-EPMC4839415 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data