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Bioinspired Artificial Nanodecoys for Hepatitis?B Virus.

ABSTRACT: A facile route is presented for fabricating a new class of nanomimics that overexpress hepatitis B virus (HBV) receptor by a natural biosynthetic procedure against HBV infection. A nine-transmembrane HBV-specific receptor, human sodium taurocholate co-transporting polypeptide (hNTCP), was engineered to naturally immobilize it onto the cellular surface and subsequently trigger the budding of hNTCP-anchoring membrane vesicles (hNTCP-MVs) that favor the HBV virion. hNTCP-MVs could rapidly block HBV infection in cell models. Furthermore, hNTCP-MVs treatment could effectively prevent viral infection, spreading, and replication in a human-liver-chimeric mouse model of HBV infection. Our findings demonstrate the receptor-mediated antiviral effect of hNTCP-MVs to trick HBV and offer novel opportunities for further development of antiviral strategies in nanomedicine.

SUBMITTER: Liu X

PROVIDER: S-EPMC6447037 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Bioinspired Artificial Nanodecoys for Hepatitis B Virus.

Liu Xuan X Yuan Lunzhi L Zhang Liang L Mu Yalin Y Li Xiaoling X Liu Chao C Lv Peng P Zhang Yali Y Cheng Tong T Yuan Quan Q Xia Ningshao N Chen Xiaoyuan X Liu Gang G

Angewandte Chemie (International ed. in English) 20180823 38

A facile route is presented for fabricating a new class of nanomimics that overexpress hepatitis B virus (HBV) receptor by a natural biosynthetic procedure against HBV infection. A nine-transmembrane HBV-specific receptor, human sodium taurocholate co-transporting polypeptide (hNTCP), was engineered to naturally immobilize it onto the cellular surface and subsequently trigger the budding of hNTCP-anchoring membrane vesicles (hNTCP-MVs) that favor the HBV virion. hNTCP-MVs could rapidly block HBV ...[more]

PMID: 30088325

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