Ontology highlight
ABSTRACT:
SUBMITTER: Taves MD
PROVIDER: S-EPMC6447081 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Taves Matthew D MD Mittelstadt Paul R PR Presman Diego M DM Hager Gordon L GL Ashwell Jonathan D JD
Cell reports 20190301 13
Glucocorticoids are lipid-soluble hormones that signal via the glucocorticoid receptor (GR), a ligand-dependent transcription factor. Circulating glucocorticoids derive from the adrenals, but it is now apparent that paracrine glucocorticoid signaling occurs in multiple tissues. Effective local glucocorticoid concentrations and whether glucocorticoid delivery can be targeted to specific cell subsets are unknown. We use fluorescence detection of chromatin-associated GRs as biosensors of ligand bin ...[more]