Ontology highlight
ABSTRACT:
SUBMITTER: Shelake S
PROVIDER: S-EPMC6447082 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Apoptosis : an international journal on programmed cell death 20190201 1-2
Current therapeutic strategies used in Ewing sarcoma (ES) especially for relapsed patients have resulted in modest improvements in survival over the past 20 years. Combination therapeutic approach presents as an alternative to overcoming drug resistance in metastatic ES. This study evaluated the effect of Clotam (tolfenamic acid or TA), a small molecule and inhibitor of Specificity protein1 (Sp1) and survivin for sensitizing ES cell lines to chemotherapeutic agent, vincristine (VCR). ES cells (C ...[more]