Early objective response to avelumab treatment is associated with improved overall survival in patients with metastatic Merkel cell carcinoma.

ABSTRACT:

Background

Response rates are primary endpoints in many oncology trials; however, correlation with overall survival (OS) is not uniform across cancer types, treatments, or lines of therapy. This study explored the association between objective response (OR) and OS in patients with chemotherapy-refractory metastatic Merkel cell carcinoma who received avelumab (anti-PD-L1).

Methods

Eighty-eight patients enrolled in JAVELIN Merkel 200 (part A; NCT02155647) received i.v. avelumab 10 mg/kg every 2 weeks until confirmed progression, unacceptable toxicity, or withdrawal. Using conditional landmark analyses, we compared OS in patients with and without confirmed OR (RECIST v1.1). We applied a Cox model that included OR as a time-varying covariate and adjusted for age, visceral diseas

SUBMITTER: D'Angelo SP 

PROVIDER: S-EPMC6447510 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature