Ontology highlight
ABSTRACT:
SUBMITTER: Lopez-Huertas MR
PROVIDER: S-EPMC6447590 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
López-Huertas Maria Rosa MR Palladino Claudia C Garrido-Arquero Marta M Esteban-Cartelle Beatriz B Sánchez-Carrillo Marta M Martínez-Román Paula P Martín-Carbonero Luz L Ryan Pablo P Domínguez-Domínguez Lourdes L Santos Ignacio De Los IL Moral Sara De La Fuente SF Benito José Miguel JM Rallón Norma N Alcamí José J Resino Salvador S Fernández-Rodríguez Amanda A Coiras Mayte M Briz Verónica V
Scientific reports 20190403 1
In HIV-1/HCV-coinfected patients, chronic HCV infection leads to an increased T-lymphocyte immune activation compared to HIV-monoinfected patients, thereby likely contributing to increase HIV-1 reservoir that is the major barrier for its eradication. Our objective was to evaluate the influence of HCV coinfection in HIV-1 viral reservoir size in resting (r) CD4+ T-cells (CD25-CD69-HLADR-). Multicenter cross-sectional study of 97 cART-treated HIV-1 patients, including 36 patients with HIV and HCV- ...[more]