Ontology highlight
ABSTRACT:
SUBMITTER: Yang LN
PROVIDER: S-EPMC6448023 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Yang Li-Ning LN Pu Jun-Cai JC Liu Lan-Xiang LX Wang Guo-Wei GW Zhou Xin-Yu XY Zhang Yu-Qing YQ Liu Yi-Yun YY Xie Peng P
Frontiers in neuroscience 20190322
Depression is a common and disabling mental disorder characterized by high disability and mortality, but its physiopathology remains unclear. In this study, we combined a non-targeted gas chromatography-mass spectrometry (GC-MS)-based metabolomic approach and isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomic analysis to elucidate metabolite and protein alterations in the hippocampus of rat after chronic social defeat stress (CSDS), an extensively used animal model of d ...[more]