Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC6448263 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Zhang Yaxiong Y Chang Lianpeng L Yang Yunpeng Y Fang Wenfeng W Guan Yanfang Y Wu Aiwei A Hong Shaodong S Zhou Huaqiang H Chen Gang G Chen Xi X Zhao Shen S Zheng Qiufan Q Pan Hui H Zhang Lanjun L Long Hao H Yang Haoxian H Wang Xin X Wen Zhesheng Z Wang Junye J Yang Hong H Xia Xuefeng X Zhao Yuanyuan Y Hou Xue X Ma Yuxiang Y Zhou Ting T Zhang Zhonghan Z Zhan Jianhua J Huang Yan Y Zhao Hongyun H Zhou Ningning N Yi Xin X Zhang Li L
Journal for immunotherapy of cancer 20190403 1
High-level tissue tumor mutational burden (tTMB) or blood TMB (bTMB) are associated with better response of immunotherapy in non-small cell lung cancer (NSCLC) patients. However, the correlations of single-region tTMB, multi-region tTMB and bTMB remain to be determined. Moreover, whether intratumor heterogeneity (ITH) has impact on TMB should be clarified. We collected multi-region tumor tissues with matched blood from 32 operative NSCLC and evaluated single-region tTMB, multi-region tTMB and bT ...[more]