A survey of risk tolerance to multiple sclerosis therapies.

ABSTRACT:

Objective

To determine tolerance to various risk scenarios associated with current multiple sclerosis (MS) therapies.

Methods

People with MS from the North American Research Committee on Multiple Sclerosis Registry's online cohort and the National Multiple Sclerosis Society were invited to complete a questionnaire on tolerance to real-world risks associated with a hypothetical therapy. Multiple risks levels were presented, including skin rash, infection, kidney injury, thyroid injury, liver injury, and progressive multifocal leukoencephalopathy (PML).

Results

Both PML and kidney injury had the lowest risk tolerance (RT) at 1:1,000,000, and thyroid and infection risks had the highest tolerance at 1:1,000. Men, younger individuals, and participants with greater disabili

SUBMITTER: Fox RJ 

PROVIDER: S-EPMC6448448 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature