Ontology highlight
ABSTRACT:
SUBMITTER: Morimoto H
PROVIDER: S-EPMC6448598 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Morimoto Hiroko H Kanastu-Shinohara Mito M Ogonuki Narumi N Kamimura Satoshi S Ogura Atsuo A Yabe-Nishimura Chihiro C Mori Yoshifumi Y Morimoto Takeshi T Watanabe Satoshi S Otsu Kinya K Yamamoto Takuya T Shinohara Takashi T
Life science alliance 20190402 2
Reactive oxygen species (ROS) play critical roles in self-renewal division for various stem cell types. However, it remains unclear how ROS signals are integrated with self-renewal machinery. Here, we report that the MAPK14/MAPK7/BCL6B pathway creates a positive feedback loop to drive spermatogonial stem cell (SSC) self-renewal via ROS amplification. The activation of MAPK14 induced MAPK7 phosphorylation in cultured SSCs, and targeted deletion of <i>Mapk14</i> or <i>Mapk7</i> resulted in signifi ...[more]