Ontology highlight
ABSTRACT:
SUBMITTER: Araiz C
PROVIDER: S-EPMC6449391 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Araiz Caroline C Yan Anqi A Bettedi Lucia L Samuelson Isabella I Virtue Sam S McGavigan Anne K AK Dani Christian C Vidal-Puig Antonio A Foukas Lazaros C LC
Nature communications 20190404 1
The insulin/IGF-1 signalling pathway is a key regulator of metabolism and the rate of ageing. We previously documented that systemic inactivation of phosphoinositide 3-kinase (PI3K) p110α, the principal PI3K isoform that positively regulates insulin signalling, results in a beneficial metabolic effect in aged mice. Here we demonstrate that deletion of p110α specifically in the adipose tissue leads to less fat accumulation over a significant part of adult life and allows the maintenance of normal ...[more]