Ontology highlight
ABSTRACT:
SUBMITTER: Frazao A
PROVIDER: S-EPMC6449444 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Frazao Alexandra A Rethacker Louise L Messaoudene Meriem M Avril Marie-Françoise MF Toubert Antoine A Dulphy Nicolas N Caignard Anne A
Frontiers in immunology 20190329
The antitumor functions of NK cells are regulated by the integration of positive and negative signals triggered by numerous membrane receptors present on the NK cells themselves. Among the main activating receptors, NKG2D binds several stress-induced molecules on tumor targets. Engagement of NKG2D by its ligands (NKG2D-Ls) induces NK cell activation leading to production of cytokines and target cell lysis. These effects have therapeutic potential as NKG2D-Ls are widely expressed by solid tumors, ...[more]