BTLA/HVEM Signaling: Milestones in Research and Role in Chronic Hepatitis B Virus Infection.
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ABSTRACT:
SUBMITTER: Yu X
PROVIDER: S-EPMC6449624 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
BTLA/HVEM Signaling: Milestones in Research and Role in Chronic Hepatitis B Virus Infection.
Yu Xueping X Zheng Yijuan Y Mao Richeng R Su Zhijun Z Zhang Jiming J
Frontiers in immunology 20190329
B- and T-lymphocyte attenuator (BTLA) is an immune-regulatory receptor, similar to CTLA-4 and PD-1, and is mainly expressed on B-, T-, and all mature lymphocyte cells. Herpes virus entry mediator (HVEM)-BTLA plays a critical role in immune tolerance and immune responses which are areas of intense research. However, the mechanisms of the BTLA and the BTLA/HVEM signaling pathway in human diseases remain unclear. This review describes the research milestones of BTLA and HVEM in chronological order ...[more]
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