Dataset Information

Effects of acute grape seed extract supplementation on muscle damage after eccentric exercise: A randomized, controlled clinical trial.

ABSTRACT:

Background/objective

High intensity eccentric exercise causes muscle damage. Polyphenol supplementation is one nutritional intervention available to limit muscle damage, but there is a lack of published data concerning the use of polyphenol-rich grape seed extract (GSE). This study investigated the effect of acute GSE supplementation on muscle damage markers after eccentric exercise.

Methods

Sixteen healthy male university students (mean age: 20.3?±?0.4 years, height: 176.1?±?4.7?cm, weight: 69.9?±?10.2?kg) were included. Participants were randomly assigned to GSE group (n?=?8) or placebo group (n?=?8); 300?mg/day of GSE or placebo was consumed from the time of eccentric exercise to 72?h after exercise. For the eccentric exercise, the elbow flexor muscle was activated using a modified preacher curl machine at 25 repetitions for 2 sets. For the muscle damage markers, maximal muscle strength, muscle soreness, and creatine kinase (CK) level were measured.

Results

There was no difference in maximal muscle strength and muscle soreness between groups in the recovery stage after eccentric exercise (p?>?0.05); CK level, a marker of cell membrane damage, was significantly decreased 96?h after exercise in the GSE group compared with the placebo group (p?ConclusionAcute GSE supplement can be an effective way to decrease cellular membrane damage after eccentric exercise. These results could be helpful in the application of GSE supplementation as a nutritional intervention to reduce muscle damage after high intensity strength training, especially in the early stage of a new strength training program. However, a larger scale study is necessary to validate these results.

SUBMITTER: Kim J

PROVIDER: S-EPMC6449740 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Publications

Effects of acute grape seed extract supplementation on muscle damage after eccentric exercise: A randomized, controlled clinical trial.

Kim Jooyoung J So Wi-Young WY

Journal of exercise science and fitness 20190103 2

<h4>Background/objective</h4>High intensity eccentric exercise causes muscle damage. Polyphenol supplementation is one nutritional intervention available to limit muscle damage, but there is a lack of published data concerning the use of polyphenol-rich grape seed extract (GSE). This study investigated the effect of acute GSE supplementation on muscle damage markers after eccentric exercise.<h4>Methods</h4>Sixteen healthy male university students (mean age: 20.3 ± 0.4 years, height: 176.1 ± 4.7  ...[more]

PMID: 30992707

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Project description:Plyometric exercise (PE) is an effective training method to increase muscle mass and strength. However, excessive or inappropriate conditions might cause exercise-induced muscle damage (EIMD). Resveratrol (RES) is a natural polyphenol plant antitoxin, which improves exercise performance, and exhibits anti-oxidation, anti-inflammatory, and anti-cancer effects. Therefore, this study investigated the effect of RES supplementation on the recovery of muscle damage, inflammation, soreness, muscle power, and anaerobic performance following plyometric-exercise-induced muscle damage (PEIMD). The present study was a double-blind, placebo-controlled research trial. Thirty-six young, untrained males were enrolled into the placebo (n = 12), RES-500 (500 mg RES/day, n = 12), or RES-1000 (1000 mg RES/day, n = 12) group by a jumping height-counterbalanced grouping design. At baseline, to pre-PEIMD, supplements were pre-loaded 7 days before they conducted PEIMD, and the exercise performance, delayed-onset muscle soreness (DOMS) and muscle damage biomarkers were measured over the experimental period at baseline, pre-PEIMD, and post-PEIMD at 2, 24, 48, and 72 h. As a result, we found that, at 72 h post-EIMD, the force peak (FP) and rate of force development (RFD) of the counter movement jump (CMJ) in RES groups showed no significant difference compared to that at baseline but was significantly greater than the placebo group. In the Wingate anaerobic test (WAnT), supplementation in the RES group had a better recovery effect on the relative peak power (RPP), relative mean power (RMP) and fatigue index (FI) (p < 0.05), especially in the high-dose group. For the detection of muscle pain after PEIMD, the RES supplement group was significantly better than the placebo group (p < 0.05). In addition, for muscle damage indexes, such as creatine kinase (CK) and lactate dehydrogenase (LDH), after PEIMD, supplementation with RES could significantly reduce and accelerate recovery (p < 0.05). In addition, the blood biochemical indicators of blood count, liver function, and kidney function showed that RES will not cause adverse risks to the human body. Our results suggest that replenishing RES in advance could effectively reduce muscle pain, increase exercise performance, and decrease muscle damage indicators caused by PEIMD, and the recovery was faster. Therefore, plyometric exercises combined with suitable RES supplementation could be an effective candidate for controlling muscle damage, improving physical adaption, and recovering anaerobic capacity.

Project description:The current consensus in exercise physiology is that the repeated bout effect always appears after few eccentric exercise sessions. This is the first attempt to challenge this tenet, by exploiting specificity in muscle plasticity. More specifically, we examined whether the opposing adaptations in muscle induced after concentric and eccentric exercise can attenuate and/or remove the repeated bout effect. Seventeen young men were randomly assigned into one of the following groups: (1) the alternating eccentric-concentric exercise group; and (2) the eccentric-only exercise group. Both groups performed 8 weeks of resistance exercise using the knee extensors of both legs on an isokinetic dynamometer. The alternating eccentric-concentric exercise group performed an alternating exercise protocol, switching between eccentric-only and concentric-only exercise every 4 weeks, while the eccentric-only group performed eccentric exercise. Evaluation of muscle damage using physiological (isometric torque, delayed onset muscle soreness, and range of movement) and biochemical (creatine kinase) markers and inflammation (C-reactive protein) was performed at weeks 1, 5, and 10. Baseline isometric peak torque was also evaluated at week 14 after another cycle (4 weeks) of alternating or eccentric-only exercise training. In the alternating eccentric-concentric exercise group, the concentric exercise training performed prior to eccentric exercise reduced dramatically the repeated bout effect by reversing muscle back to its unaccustomed state. On the contrary, the eccentric-only exercise group exhibited a typical manifestation of the repeated bout effect. Interestingly, muscle strength was elevated similarly for both alternating and eccentric-only exercise groups after 13 weeks of training. The alternating eccentric-concentric exercise scheme, implemented in the present study, has for the first time successfully overcame the repeated bout effect. The similarity in muscle strength measurements following the two protocols is against the notion that inflammation plays an important role in exercise-induced adaptations in muscle.

Project description:Purpose:This systematic review and meta-analysis was performed to determine the effectiveness of Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplement on muscle soreness after eccentric exercise. Methods:PubMed, EMBASE, CENTRAL, and ISI Web of Science were searched to identify randomized controlled trials (RCTs) that assessed the efficacy of n-3 PUFA on muscle soreness after eccentric exercise. Mean difference (MD) and the associated 95% confidence interval (95% CI) were calculated by RevMan 5.3 to indicate delayed onset muscle soreness (DOMS) that measured two days after eccentric trainings. Subgroup analyses according to duration and daily dosage of n-3 PUFA supplements before eccentric exercises were performed to determine whether these factors will influence the overall effect size. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach was used to evaluate the certainty of evidence. The protocol of this systematic review and meta-analysis was registered at PROSPERO (CRD42018085869). Results:12 RCTs containing 145 subjects and 156 controls were included in this study. Meta-analysis revealed a significantly decreased DOMS (MD -0.93; 95% CI -1.44, -0.42; P = 0.0004) in n-3 PUFA supplement groups, while no significant differences in isometric muscle strength and range of motion (ROM) were detected. However, the pooled effect size for DOMS was lower than the minimal clinically important difference (MCID) of 1.4 on the 10-unit VAS, suggesting that the effect size of less muscle soreness with n-3 PUFA supplements did not appear to be clinically relevant. Conclusion:There is low-quality evidence that n-3 PUFA supplementation does not result in a clinically important reduction of muscle soreness after eccentric exercise. Isometric muscle soreness and range of motion were not improved by n-3 PUFA supplementation either (low-quality evidence). To further elucidate the overall role of n-3 PUFA on muscle damage in this area, large-scale RCTs are still needed.

Dataset Information

Effects of acute grape seed extract supplementation on muscle damage after eccentric exercise: A randomized, controlled clinical trial.

Background/objective

Methods

Results

Publications

Effects of acute grape seed extract supplementation on muscle damage after eccentric exercise: A randomized, controlled clinical trial.

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