Ontology highlight
ABSTRACT:
SUBMITTER: Nayak A
PROVIDER: S-EPMC6450077 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Nayak Arabinda A Kim Dong Young DY Trnka Michael J MJ Kerr Craig H CH Lidsky Peter V PV Stanley David J DJ Rivera Brianna Monique BM Li Kathy H KH Burlingame Alma L AL Jan Eric E Frydman Judith J Gross John D JD Andino Raul R
Cell host & microbe 20181001 4
The dicistrovirus, Cricket paralysis virus (CrPV) encodes an RNA interference (RNAi) suppressor, 1A, which modulates viral virulence. Using the Drosophila model, we combined structural, biochemical, and virological approaches to elucidate the strategies by which CrPV-1A restricts RNAi immunity. The atomic resolution structure of CrPV-1A uncovered a flexible loop that interacts with Argonaute 2 (Ago-2), thereby inhibiting Ago-2 endonuclease-dependent immunity. Mutations disrupting Ago-2 binding a ...[more]