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Hypermutations in porcine respiratory and reproductive syndrome virus.

ABSTRACT: Porcine reproductive and respiratory syndrome (PRRS), which is caused by the PRRS virus (PRRSV), has resulted in large economic losses for the swine industry. The virus has shown remarkable genetic diversity since its discovery. In our study, we investigated mutation types in the evolution of PRRSV for both in vivo and in vitro passaging of the virus. Sequence alignment analysis demonstrated that the most common hypermutations expressed were A?G/U?C and G?A/C?U. The data provide a new theoretical basis for PRRSV evolution.

SUBMITTER: Dong J 

PROVIDER: S-EPMC6450159 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Hypermutations in porcine respiratory and reproductive syndrome virus.

Dong Jianguo J   Rao Dan D   Ding Yushan Y   Zhao Yu Y   Zhang Guangqiang G   Deng Kaiwei K   Liu Tao T   Jiao Fengchao F   Hu Jing J   Wang Huanan H   Zhang Ning N   Zhao Pandeng P   Leng Chaoliang C  

Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20190401 2

Porcine reproductive and respiratory syndrome (PRRS), which is caused by the PRRS virus (PRRSV), has resulted in large economic losses for the swine industry. The virus has shown remarkable genetic diversity since its discovery. In our study, we investigated mutation types in the evolution of PRRSV for both <i>in vivo</i> and <i>in vitro</i> passaging of the virus. Sequence alignment analysis demonstrated that the most common hypermutations expressed were A→G/U→C and G→A/C→U. The data provide a  ...[more]

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